Little Known Facts About ceesdekker.
Little Known Facts About ceesdekker.
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‘The next is nanopores, that's our oldest line of exploration and that has now resulted in DNA sequencers based upon nanopores. We pull unique DNA strands via a nanopore and might then read through off the nucleotide sequence. Really not too long ago, we even managed to go through out just one protein for the first time using This system. But this line of exploration is not simply about building resources, but also about real Organic issues.
Our group research bacterial mobile division and is particularly aiming to represent a ‘bottom up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
Back again in 1991, Sumio Iijima in the NEC Corporation had noted the synthesis of carbon nanotubes. Band construction calculations proposed that these nanotubes could exhibit metallic band conduction. This might be a major edge in excess of the conducting polymers we had explored, which were, in fact, disordered semiconductors offering merely variable-range hopping conductivity.
2007, to start with genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You're a Christian. If you can make this kind of synthetic mobile, would you be a single step nearer to God, or would the role of God have diminished rather once more?
Flow-driven rotary motors including windmills and drinking water wheels push purposeful procedures in human Modern society. Even though ceesdekker examples of this sort of rotary motors also attribute prominently in mobile biology, their artificial development for the nanoscale has remained complicated. In this article we demonstrate flow-driven rotary motion of the self-structured DNA nanostructure that is docked onto a nanopore in a skinny solid-point out membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking on to the good-point out nanopore, and subsequently shows a sustained unidirectional rotary movement of up to twenty rev s−1.
Imagine if, as opposed to applying typical top-down silicon electronics, transistors may very well be constructed from The underside up utilizing one organic molecules as being the switching components? This concept, which turned the basis of now’s subject of molecular electronics, initial emerged while in the 1970s.
There was one particular dilemma while — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers have been in fact not these good conductors, which was alternatively disappointing. We So broadened our perspective to test to search out additional promising molecules.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
Afterwards we spoke once again briefly mainly because Dekker felt that our dialogue of his religion quickly became purely philosophical, whereas Furthermore, it concretely can help him in his do the job.
2008, initial observation of protein-coated DNA translocation via nanopores; resolved the origin of the electrophoretic force on DNA in nanopores; found a significant velocity increase of microtubules in electric powered fields; found out an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style and design in 2005. (nl)